Adult MBSR Evidence for Anxiety
Some of the best available evidence for MBSR in the management of anxiety disorders includes meta-analytic studies and RCTs. These are described below in date order, starting with the most recent.
The first is a meta-analytic study conducted to determine the effectiveness of acceptance and mindfulness-based approaches across DSM-5 anxiety disorders (5). Analysis included 23 studies, mostly of unclear risk of bias, included 1,815 adults with different DSM-5 anxiety disorders. Eight of the included RCTs involved MBSR. Individual- and group-based approaches were included as well as online and offline/in-person settings. Control interventions included TAU/wait-list, individualized or group-based CBT, psychoeducation, and relaxation.
Another meta-analytic study was conducted to determine the effectiveness of psychological interventions in the treatment of anxiety, depression and stress in students (6). Analysis of anxiety interventions included 26 studies, involving 2,602 students with ages that ranged between 6-53 years. The students were in university (17 studies), secondary (7 studies) and primary education (2 studies). Sub-group analysis based on intervention strategy was conducted, so mindfulness-based programmes were analysed as one group. Subgroup analysis based on the types of mindfulness interventions (e.g. MBSR or MBCT) was not conducted. Subgroup analysis based on the educational ages of the students for those that received mindfulness interventions was not conducted. The anxiety diagnostic instruments used in the included studies were mentioned, however, the review did not restrict eligibility criteria to include only studies with clinical populations.
The third was an RCT that was conducted to determine the effectiveness of MBSR on acute stress responses in adults (aged 18 years or over) diagnosed with GAD (7,8). The study included 93 adults who were randomised to receive either MBSR or an attention control class. MBSR was delivered as an 8-week group-based intervention, with a single weekend “retreat” day, and daily home practice guided by audio recordings. The study was conducted in the USA.
The fourth was an RCT conducted to compare adapted MBSR to cognitive behavioural therapy (CBT) for the group treatment of anxiety disorders (9). The study included 105 Veterans, aged 18-75 years, with a principal (or dual principal) anxiety diagnosis (including panic disorder/agoraphobia (PD/AG), generalized anxiety disorder (GAD), and social anxiety disorder (SAD). Adapted MBSR was delivered over ten 90-minute group sessions, 3-hour retreat, and 20-30 minutes of homework-practice meditations. The study was conducted in the USA.
The fifth was a meta-analytic study conducted to determine the effectiveness of mindfulness and acceptance-based interventions for the treatment of anxiety disorders (10). The review included 19 studies with 491 participants with ages that ranged from 22 to 51 years. Participants had a primary diagnosis of anxiety disorders that included SAD in 7 studies, GAD in 4 studies, mixed anxiety disorders in 4 studies, anxiety and/or comorbid depression in 3 studies, and panic disorder in 1 study. MBSR was evaluated in 4 studies and MBCT was evaluated in 8 studies. Separate comparative analysis was reported for MBSR and MBCT.
The sixth was an RCT that was conducted to determine the effectiveness of MBSR in patients with heterogeneous anxiety disorders (11). The study included 76 adults, aged 18-65 years, diagnosed with panic disorder with or without agoraphobia (PD/AG), social anxiety disorder (SAD), or generalized anxiety disorder (GAD). MBSR was delivered in eight weekly 2.5-hour sessions, a half-day meditation retreat, daily home practice, and daily record keeping of mindfulness exercises. The study was conducted in Norway.
The seventh was a meta-analytic study conducted to determine the effectiveness of mindfulness-based interventions (MBIs) on anxiety and depression (12). The review included 39 studies consisting of 1,140 participants (aged 18-65 years) with diagnosable psychological or physical/medical disorders. The studies included those conducted in participants with generalized anxiety disorder (n=5), depression (n=4), and panic disorder (n=3). MBIs in this review included those that employed MBSR or MBCT, or were modelled on MBSR or MBCT. Meta-analysis for MBSR and MBCT studies were reported separately.
Adult Outcomes for Anxiety
Compared to control groups, the following outcomes were observed;
- Significantly reduced or significantly greater reduction in anxiety symptoms at post-treatment (6,8,10-12), sustained at 6-months follow-up (11,12).
- In comparison to Cognitive Behavioural Therapy (CBT), MBSR showed significantly lower effects on patient and clinician rated anxiety. Analyses up to 6 and 12 months did not reveal significant differences compared to TAU or CBT (5).
- Significantly reduced severity of principal anxiety disorder, sustained at 3-months follow-up for within group analysis (9).
- Significantly reduced depression measures at post-treatment and 6-months follow-up (11,12).
- Significantly greater reduction in stress markers post-treatment (7).
- Significantly greater increase in agreement with the positive statements (8).